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KMID : 1234520080030020197
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Korean Journal of Urogenital Tract Infection Inflammation
2008 Volume.3 No. 2 p.197 ~ p.201
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Chemopreventive Effect of Aspirin on the Prostate Cancer
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Cho Soung-Yong
Cho In-Rae
Song Hyun-Dong
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Abstract
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Purpose: The study is carried out to investigate the influence of chronic prostatitis history on the risk factor of prostate cancer.
Materials and methods: The investigation was proceeded with 64 patients diagnosed with prostate cancer through prostate biopsy from 2003 to 2006. We have surveyed the past history of prostatitis of the prostate cancer patients by a questionaires. The existence and nonexistence of past history of prostatitis divided the prostate cancer patients into two groups. We compared the differences between the groups of prostate cancer patients with the gleason score, clinical stage, prostate volume, prostate specific antigen (PSA), prostate specific antigen density (PSAD), node invasion and metastatic lesion.
Results: There were 15 patients (23.4%) among prostate cancer patients. In case of prostate cancer patients with past history of prostatitis, the mean age was 73.7±7.4, prostate volume 50.4±27.2ml, PSA 91.8±125.5 ng/ml, PSAD 1.8±2.8, respectively. The number of patients without past history of prostatitis were 49 and the mean age was 74.7±5.3years, prostate volume 43.2±20.4ml, PSA 33.9±46.1ng/ml and PSAD 0.7±0.8. There was significant difference in PSA and PSAD, but in the other factors were not. With Gleason score, clinical stage, node invasion and metastasis, there was no significant difference respectively.
Conclusion: Our study demonstrates that the past history of prostatitis in prostate cancer patients increases the PSA. The past history of prostatitis may have influence on the PSA, and it can cause for confusion with the prognostic evaluation of prostate cancer.
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KEYWORD
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Aspirin, Prostate, Inflammation, Cancer
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